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1.
Conformational interdomain flexibility in a bacterial α-isopropylmalate synthase is necessary for leucine biosynthesis.
J Biol Chem
; 299(2): 102789, 2023 02.
Article
in English
| MEDLINE | ID: mdl-36509144
2.
Precise Positioning of Water Is Critical for Hydrolysis Catalyzed by 5'-Methylthioadenosine Nucleosidase.
Biochemistry
; 61(17): 1883-1893, 2022 09 06.
Article
in English
| MEDLINE | ID: mdl-35969806
3.
The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues.
Bioorg Med Chem
; 74: 117038, 2022 11 15.
Article
in English
| MEDLINE | ID: mdl-36209571
4.
A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis.
J Biol Chem
; 295(19): 6252-6262, 2020 05 08.
Article
in English
| MEDLINE | ID: mdl-32217694
5.
Computational investigations of allostery in aromatic amino acid biosynthetic enzymes.
Biochem Soc Trans
; 49(1): 415-429, 2021 02 26.
Article
in English
| MEDLINE | ID: mdl-33544132
6.
Hinge Twists and Population Shifts Deliver Regulated Catalysis for ATP-PRT in Histidine Biosynthesis.
Biophys J
; 116(10): 1887-1897, 2019 05 21.
Article
in English
| MEDLINE | ID: mdl-31053263
7.
A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase.
Biochem J
; 475(1): 247-260, 2018 01 05.
Article
in English
| MEDLINE | ID: mdl-29208762
8.
Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors.
Biochim Biophys Acta Bioenerg
; 1859(7): 482-490, 2018 Jul.
Article
in English
| MEDLINE | ID: mdl-29621505
9.
'Tethering' fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase.
Bioorg Med Chem Lett
; 28(13): 2239-2243, 2018 07 15.
Article
in English
| MEDLINE | ID: mdl-29859905
10.
Probing the determinants of phosphorylated sugar-substrate binding for human sialic acid synthase.
Biochim Biophys Acta
; 1844(12): 2257-64, 2014 Dec.
Article
in English
| MEDLINE | ID: mdl-25242570
11.
Substrate-mediated control of the conformation of an ancillary domain delivers a competent catalytic site for N-acetylneuraminic acid synthase.
Proteins
; 82(9): 2054-66, 2014 Sep.
Article
in English
| MEDLINE | ID: mdl-24633984
12.
Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets.
ACS Cent Sci
; 10(2): 344-357, 2024 Feb 28.
Article
in English
| MEDLINE | ID: mdl-38435523
13.
Arg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidis.
Biochemistry
; 52(15): 2609-19, 2013 Apr 16.
Article
in English
| MEDLINE | ID: mdl-23534460
14.
Structure, mechanism and inhibition of anthranilate phosphoribosyltransferase.
Philos Trans R Soc Lond B Biol Sci
; 378(1871): 20220039, 2023 02 27.
Article
in English
| MEDLINE | ID: mdl-36633281
15.
Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: a feedback inhibition mechanism of the menaquinone biosynthesis pathway.
Philos Trans R Soc Lond B Biol Sci
; 378(1871): 20220035, 2023 02 27.
Article
in English
| MEDLINE | ID: mdl-36633276
16.
The discovery of 12ß-methyl-17-epi-18-nor-bile acids as potent and selective TGR5 agonists.
Eur J Med Chem
; 250: 115143, 2023 Mar 15.
Article
in English
| MEDLINE | ID: mdl-36841086
17.
Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.
Nat Commun
; 14(1): 4204, 2023 07 14.
Article
in English
| MEDLINE | ID: mdl-37452046
18.
Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design.
J Biol Chem
; 286(18): 16197-207, 2011 May 06.
Article
in English
| MEDLINE | ID: mdl-21454647
19.
New tripeptide-based macrocyclic calpain inhibitors formed by N-alkylation of histidine.
Chem Biodivers
; 9(11): 2473-84, 2012 Nov.
Article
in English
| MEDLINE | ID: mdl-23161629
20.
Synthesis of Novel Glycolipid Mimetics of Heparan Sulfate and Their Application in Colorectal Cancer Treatment in a Mouse Model.
Chem Asian J
; 17(12): e202200228, 2022 Jun 15.
Article
in English
| MEDLINE | ID: mdl-35427432